Interaction of Cialis Plus and its storage conditions

With the help of Cialis Plus you can surprise your beloved with the erection quality, give her an unforgettable experience and return the taste of natural sexual relations! If you are going to buy Cialis Super Active Plus or any other medicine for erectile dysfunction treatment, you should know that each substance has its own effective date and conditions, which are preferable to prolong the serviceable life.In case you store the drug without following the instructions, don’t be surprised if the medicine doesn’t work as it must. Due to the wrong storage conditions Cialis may lose its great properties used for the treatment of erection problems. That’s be careful getting acquainted with the recommendations how to use and store Cialis Plus before you start taking it.

Cialis plus is available in blister packs containing 10 gelatin capsules of the yellow color. Like the original Cialis its generic Cialis Plus contains a daily dose of Tadalafil, which is 20 mg (the optimal dose sufficient for successful intercourse). Cialis increases blood flow into the corpora cavernosa of the penis due to the potentiation of vasodilatory action of nitric oxide, released during sexual excitement from the nerve endings innervating the penis. The feature that makes Cialis generic different from its original version is the improved formula. The drug formulation is considered to be more effective thanks to the gel disposed in the capsule. Such a dosage form can help the drug to instantly get into the blood and guarantee the high efficiency of the drug in the fight against erectile dysfunction of various origins.

More about Fast ED treatment. Cialis | Read more >>

 

Things to keep in mind when you store Cialis

According to Cialis Super Active instructions it is recommended to meet follow the rules listed below if you want your drug remain effective till its expiration date:

  • Cialis Super Active should be stored in a dark place, the temperature of which must not me more than 30 degrees Celsius

In case the temperature is higher than 30, the drug will lose its properties and can be spoiled before the expiration date, moreover after long stay in heat it may be not safe to use it.

  • Cialis should be stored in its original packaging;

It is better to keep Cialis the same way as you have bought it as it is the best suitable way to protect it from any harmful influence of sunlight or other factors.

  • Cialis must be placed in a safe place, protected from children and animals;

Cialis storageThis point should be kept in mind in order nobody besides you can use your drug for erectile dysfunction as it is intended to be used only for men suffering from erection problems and contraindicated to be administered by children younger than 18 years old. It is obvious that if your pet finds it and eat, it can be rather dangerous as well. That’s why keep Cialis in some safe place where it is going to be unreachable for anybody, except the person who uses the drug for the treatment purpose.

What to know about interaction of Cialis with other drugs?

What to do if you want to take Cialis and need to use some other drug simultaneously? In order to get the desired effect after using Cialis it is necessary to consult your doctor in order he/she approves the interaction of Tadalafil (Cialis online) and other substances.

Be aware of the influence of other drugs on tadalafil:

  • Tadalafil is mainly metabolized with the participation of isoenzyme CYP3A4. Selective inhibitor of isozyme CYP3A4 ketoconazole (400 mg daily) increases the exposure of a single dose of tadalafil (AUC) for 312% and Cmax by 22%, ketoconazole (200 mg daily) increases the exposure of a single dose of tadalafil (AUC) 107% and a Cmax at 15% relative to the AUC and Cmax values ​​for only one of tadalafil.
  • Ritonavir (200 mg twice daily), an inhibitor of CYP3A4,2S9,2S19 and 2D6, increases the exposure of a single dose of tadalafil (the AUC) by 124% without changing the C max.
  • Despite the fact that the specific interactions have not been studied, it is possible to assume that other HIV protease inhibitors such as saquinavir, as well as inhibitors isoenzyme CYP3A4, such as itraconazole, and erythromycin, increase the activity of tadalafil.
  • Isozyme selective inducer of CYP3A4, rifampicin (600 mg daily), reduces the exposure of a single dose of tadalafil (AUC) at 88% and at 46% Cmax, AUC and relative Cmax values ​​ only for tadalafil.
  • The simultaneous use of other inducers of CYP3A4 should also reduce the concentration of tadalafil in plasma.
  • The simultaneous treatment with an antacid (hydroxide / magnesium aluminum hydroxide) and tadalafil is able to decrease the rate of absorption of tadalafil without altering the area under the concentration-time curve for tadalafil.
  • Increasing the pH of the stomach as a result of receiving blocker H2-histamine receptors nizatidine has no effect on tadalafil pharmakocinetics.
  • Safety and efficacy of combinations of Cialis with other drugs for erectile dysfunction have not been studied, so the use of such combinations is not recommended.
  • Tadalafil does not potentiate the increase in bleeding time caused by taking aspirin.

Which effect does Tadalafil have on other drugs?

  • It is known that tadalafil amplifies hypotensive effects of nitrates. This is due to the additive effect of nitrates and tadalafil on the metabolism of nitric oxide II (NO) and cGMP. Therefore, the use of tadalafil is contraindicated.to patients who get nitrates at the moment.
  • Tadalafil has no clinically significant effect on clearance of drugs, the metabolism of which proceeds with the participation of cytochrome P450.
  • Tadalafil has no clinically significant effect on S-warfarin or R-varfarnna. Tadalafil doesn’t affect the action of warfarin on prothrombin time.
  • Tadalafil does not increase the duration of bleeding caused by acetylsalicylic acid.
  • Cialis has a systemic vasodilating properties and may exacerbate the effects of antihypertensive drugs aimed at lowering blood pressure.
  • Additionally, patients taking multiple antihypertensive agents whose hypertension is poorly controlled may have a slightly higher blood pressure reduction.
  • Patients receiving treatment with antihypertensive drugs together with tadalafil should have an appropriate doctor’s consultation.
  • There was no significant reduction in blood pressure while combining Cialis with selective alfa1A-blocker tamsulosin.
  • Concomitant use of tadalafil with doxazosin is contraindicated. When using tadalafil in healthy volunteers who had doxazosin (4-8 mg per day), alpha 1-blocker, hypotensive action of the latter was Some patients have experienced dizziness.
  • Tadalafil doesn’t affect the concentration of alcohol, as well as alcohol does not affect the concentration of tadalafil. At high doses of alcohol (0.7 g / kg) does not cause significant reduction in the average blood pressure